CHAPTER 4 - Discovery and Development of Antiviral Drugs for Treatment of Pathogenic Human Orthopoxvirus Infections
Identifieur interne : 001A30 ( Main/Exploration ); précédent : 001A29; suivant : 001A31CHAPTER 4 - Discovery and Development of Antiviral Drugs for Treatment of Pathogenic Human Orthopoxvirus Infections
Auteurs : Robert Jordan [États-Unis]Source :
- RSC Drug Discovery [ 2041-3203 ]
Abstract
Smallpox, a devastating disease with mortality rates of upwards of 30%, ravaged humanity for thousands of years until it was eradicated in the latter half of the twentieth century by a successful vaccination campaign sponsored by the World Health Organization. Smallpox was caused by infection with variola virus, one of several orthopoxviruses that infect humans and cause disease. Although smallpox no longer exists in the environment, concern that variola virus or a related orthopoxvirus could be developed into a bioweapon prompted the US government to sponsor research into developing antiviral drugs to treat variola virus infection. Antiviral drug development for orthopoxvirus infections is hampered by the lack of human disease, requiring the use of animal models to establish pharmacokinetic–pharmacodynamic relationships to guide effective human dosing strategies. Cidofovir, CMX001 and ST‐246 are clinical‐stage compounds currently being evaluated for the treatment of pathogenic orthopoxvirus infections. Cidofovir is an acyclic nucleoside phosphonate that targets the viral polymerase and CMX001 is an oral prodrug of cidofovir designed to improve oral bioavailability and safety. ST‐246 is a novel chemical entity that blocks viral egress. Although all three compounds are effective at treating orthopoxvirus infections in animal models, and are safe and well tolerated in human clinical trials, establishing effective human dosing strategies using animal efficacy data remains a major challenge for the development of these therapeutics.
Url:
DOI: 10.1039/9781849737814-00081
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001C02
- to stream Istex, to step Curation: 001C02
- to stream Istex, to step Checkpoint: 000308
- to stream Main, to step Merge: 001A40
- to stream Main, to step Curation: 001A30
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>CHAPTER 4 - Discovery and Development of Antiviral Drugs for Treatment of Pathogenic Human Orthopoxvirus Infections</title>
<author><name sortKey="Jordan, Robert" sort="Jordan, Robert" uniqKey="Jordan R" first="Robert" last="Jordan">Robert Jordan</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:A75ED242DFE23D1B639E169B83452BE1A296926D</idno>
<date when="2013" year="2013">2013</date>
<idno type="doi">10.1039/9781849737814-00081</idno>
<idno type="url">https://api.istex.fr/ark:/67375/P0J-RPCX6LZK-W/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001C02</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001C02</idno>
<idno type="wicri:Area/Istex/Curation">001C02</idno>
<idno type="wicri:Area/Istex/Checkpoint">000308</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000308</idno>
<idno type="wicri:doubleKey">2041-3203:2013:Jordan R:chapter:discovery:and</idno>
<idno type="wicri:Area/Main/Merge">001A40</idno>
<idno type="wicri:Area/Main/Curation">001A30</idno>
<idno type="wicri:Area/Main/Exploration">001A30</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a">CHAPTER 4 - Discovery and Development of Antiviral Drugs for Treatment of Pathogenic Human Orthopoxvirus Infections</title>
<author><name sortKey="Jordan, Robert" sort="Jordan, Robert" uniqKey="Jordan R" first="Robert" last="Jordan">Robert Jordan</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>a Gilead Sciences, Inc. 333 Lakeside Drive, Foster City</wicri:cityArea>
</affiliation>
<affiliation></affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="s">RSC Drug Discovery</title>
<idno type="ISSN">2041-3203</idno>
<idno type="eISSN">2041-3211</idno>
<idno type="ISSN">2041-3203</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">2041-3203</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract">Smallpox, a devastating disease with mortality rates of upwards of 30%, ravaged humanity for thousands of years until it was eradicated in the latter half of the twentieth century by a successful vaccination campaign sponsored by the World Health Organization. Smallpox was caused by infection with variola virus, one of several orthopoxviruses that infect humans and cause disease. Although smallpox no longer exists in the environment, concern that variola virus or a related orthopoxvirus could be developed into a bioweapon prompted the US government to sponsor research into developing antiviral drugs to treat variola virus infection. Antiviral drug development for orthopoxvirus infections is hampered by the lack of human disease, requiring the use of animal models to establish pharmacokinetic–pharmacodynamic relationships to guide effective human dosing strategies. Cidofovir, CMX001 and ST‐246 are clinical‐stage compounds currently being evaluated for the treatment of pathogenic orthopoxvirus infections. Cidofovir is an acyclic nucleoside phosphonate that targets the viral polymerase and CMX001 is an oral prodrug of cidofovir designed to improve oral bioavailability and safety. ST‐246 is a novel chemical entity that blocks viral egress. Although all three compounds are effective at treating orthopoxvirus infections in animal models, and are safe and well tolerated in human clinical trials, establishing effective human dosing strategies using animal efficacy data remains a major challenge for the development of these therapeutics.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Californie</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Californie"><name sortKey="Jordan, Robert" sort="Jordan, Robert" uniqKey="Jordan R" first="Robert" last="Jordan">Robert Jordan</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001A30 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001A30 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:A75ED242DFE23D1B639E169B83452BE1A296926D |texte= CHAPTER 4 - Discovery and Development of Antiviral Drugs for Treatment of Pathogenic Human Orthopoxvirus Infections }}
This area was generated with Dilib version V0.6.33. |